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A titular see of Cilicia Secunda in Asia Minor and suffragan of Anazarbus. The founding of this city is attributed to the soothsayer, Mopsus, who lived before the Trojan war, although it is scarcely mentioned before the Christian era. Pliny calls it the free city of Mopsos (Hist. nat., V, 22), but the ordinary name is Mopsuestia or better Mompsuestia, as found in all the Christian geographers and chroniclers. At one time the city took the name of Seleucia, but gave it up at the time of the Roman conquest; under Hadrian it was called Hadriana, under Decius Decia, etc., as we know from the inscriptions and the coins of the city. Constantius built there a magnificent bridge over the Pyramus (Malalas, "Chronographia", XIII; P.G., XCVII, 488) afterwards restored by Justinian (Procopius, "De Edificiis", V. 5) and still to be seen in a very bad state of preservation. Christianity seems to have been introduced very early into Mopsuestia and during the third century there is mention of a bishop, Theodorus, the adversary of Paul of Samosata. Worthy of mention are Saint Auxentius, who lived in the fourth century and whose feast is kept on 18 December, and Theodore, the teacher of Nestorius. The Greek diocese which depended on the Patriarch of Antioch, still existed at the beginning of the fourteenth century (Le Quien "Oriens Christianus", II, 1002). At first a suffragan of Anazarbus, Mopsuestia was an autocephalous archbishopric in 879 (Mansi, "Concil. Collectio", XVII, XVIII, 472, 476-480, etc.), and perhaps it was already so in 713 (Le Quien, Il, 1000). The city was taken by the Arabs at the very beginning of Islamism; in 686 we find all the surrounding forts occupied by them and in 700 they fortified the city itself (Theophanes, "Chronogr.", A. M. 6178, 6193). Nevertheless because of its position on the frontier, the cify fell naturally from time to time into the hands of the Byzantines, about 772 its inhabitants killed a great member of Arabs (op. cit., A. M. 6264). Being besieged in vain by the Byzantine troops of John Tzimisces in 964, Mopsuestia was taken the following year after a long and difficult siege by Nicephorus Phocas. The city then numbered 200,000 inhabitants, some of whom were killed, some transported elsewhere and replaced by a Christian population. Its river, the Pyramus, formed a great harbour extending twelve miles to the sea.
In 1097 the Crusaders took possession of the city and engaged in a fratricidal war under its walls; it remained in the possession of Tancred who annexed it to the Principality of Antioch. It suffered much from Crusaders, Armenians, and Greeks who lost it and recaptured it alternately notably in 1106, in 1152, and in 1171. The Greeks finally abandoned it to the Armenians. Set on fire in 1266, Mamissa, as it was called in the Middle Ages, became two years afterwards the capital of the Kingdom of Lesser Armenia, at the time that a council was held there. Although it was by this time in a state of decline it still possessed at least four Armenian churches. In 1322, the Armenians suffered a great defeat under its walls, in 1432 the Frenchman, Bertrandon, found the city occupied by the Mussulmans and largely destroyed. Since then it has steadily declined and today, under the name of Missis, is a little village of about 800 inhabitants, partly Armenians, partly Mussulmans; it is situated in the sanjak and the vilayet of Adana. The list of its Latin bishops may be found in Le Quien, III, 1197-200; in Ducange, "Les families d'outre-mer", 770; in Eubel. "Hierarchia catholica medii aevi", I, 338; that of the Armenian bishops in Alishan, "Sissouan", 290.
ALISHAN, Sissouan (Venice, 1899), 284-291; LANGLOIS, Voyage dans la Citicie (Paris, 1861), 446-463: SCHLUMBERGER, Nicephore Phocas (Paris, 1890), 402-404, 480-488.